Acute Kidney Injury during pregnancy


  • Alexandre Hertig Service de Néphrologie, Hôpital Foch, 40 rue Worth, 92150 Suresnes, France
  • Marie Carbonnel Service de Gynécologie-Obstétrique, Hôpital Foch, 40 rue Worth, 92150 Suresnes, France
  • Charles Cerf Service de Réanimation polyvalente, Hôpital Foch, 40 rue Worth, 92150 Suresnes, France



Acute Kidney Injury, Placenta, Pregnancy, Thrombotic microangiopathy


In intensive care units, taking care of pregnant women developing acute kidney injury [AKI] pre- or immediately post-partum implies to know the high susceptibility of maternal endothelium. The latter is induced by the presence of a placenta which physiologically produces large amounts of anti-angiogenic factors such as sFlt-1. The main mechanism of AKI is acute tubular necrosis, most probably of ischemic nature. However, when AKI develops contemporarily of a HELLP syndrome (Hemolysis Enzyme Liver Low Platelets),  i.e. of a thrombotic microangiopathy, the differential diagnostic procedure may be highly complex : other causes, exceptional, but calling for more specific therapies than delivery, must indeed be contemplated by the intensivist. In such circumstances, uncover the effect of time alone is key.  




How to Cite

Hertig, A., Carbonnel, M., & Cerf, C. (2022). Acute Kidney Injury during pregnancy. Médecine Intensive Réanimation, 31(4), 323–330.

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