Induction of Diuresis and Natriuresis for Renal Protection: Update on the RenalGuard System™

Abstract

“Forced diuresis” is a technique that involves inducing a high urine flow rate. In most circumstances, diuretics and intravenous fluid replacement are necessary. Forced diuresis is recommended in a number of circumstances to improve or protect kidney function. The technique can be difficult to manage in clinical practice, often leading to net volume loss or excess. In this article, we review the data on the use of the RenalGuard system™. RenalGuard^® accurately matches urine output and intravenous fluid input in real time and prevents any net volume changes. To date, RenalGuard^® has been studied for prevention of acute kidney injury in patients undergoing cardiac angiography, percutaneous coronary intervention, and transcatheter aortic valve implantation. The possible mechanisms involved in producing a benefit are discussed.