Sepsis-induced coagulopathy

Authors

  • Julie Helms 1.  INSERM, UMR 1260, Nanomédecine Régénérative (RNM), FMTS, Strasbourg, France. 2. Université de Strasbourg (UNISTRA), Faculté de Médecine ; Hôpitaux universitaires de Strasbourg, Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Strasbourg, France
  • Marine Tschirhart INSERM, UMR 1260, Nanomédecine Régénérative (RNM), FMTS, Strasbourg, France
  • Anaïs Curtiaud Université de Strasbourg (UNISTRA), Faculté de Médecine ; Hôpitaux universitaires de Strasbourg, Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, Strasbourg, France
  • Laurent Sattler Hôpitaux universitaires de Strasbourg, Laboratoire d’Hématologie, Hautepierre, Strasbourg, France

DOI:

https://doi.org/10.37051/mir-00122

Keywords:

sepsis, septic shock, microvesicles, immunothrombosis, coagulopathy, disseminated intravascular coagulation

Abstract

Disseminated intravascular coagulation (DIC) is a common complication of sepsis and septic shock. While coagulation activation during sepsis, along with the involvement of innate immunity, participates in the host's defense against the pathogen (immunothrombosis), its activation is deregulated with a defect in anticoagulant and fibrinolytic regulators in DIC, results in the formation of multiple microthrombosis contributing to multiorgan failure and increased mortality in these patients. This review reports the latest pathophysiological, diagnostic and therapeutic advances in septic DIC.

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Published

2022-12-23

How to Cite

Helms, J., Tschirhart, M., Curtiaud, A., & Sattler, L. (2022). Sepsis-induced coagulopathy. Médecine Intensive Réanimation, 31(4), 313–322. https://doi.org/10.37051/mir-00122

Issue

Vol. 31 No. 4 (2022): Octobre-Décembre

Section

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