Bradykinin-mediated angioedema

Abstract

Bradykinin-mediated angioedema (AE) is characterized by periodic subcutaneous or submucosal swelling, with the absence of urticaria and itching. AE involves the face and extremities. Attacks of abdominal pain and obstruction of the upper airways are the hallmarks of disease severity. There are hereditary and acquired forms, including cases secondary to the administration of converting enzyme-inhibitors. Acute attacks are treated by early administration of specific treatments, including icatibant, an inhibitor of bradykinin B2 receptor and C1-inhibitor concentrate.