Mitochondrie — rôles clés dans le sepsis

Abstract

The pathophysiological mechanisms underpinning the development of, and recovery from, sepsis-induced organ failure require further delineation. Mitochondrial dysfunction may well play a key role. This review will therefore consider mitochondria’s function in normal physiology, evidence linking bioenergetic alterations to organ dysfunction after severe and prolonged inflammation, and potential therapeutic strategies that may be applied.