Acute kidney injury in patient with severe SARS-CoV-2 infection

Authors

  • Paul Gabarre médecine intensive réanimation, hopital Saint Louis
  • Guillaume Dumas Service de Médecine Intensive Réanimation, Hôpital Saint Louis, Assistance Publique des Hôpitaux de Paris
  • Lara Zafrani 1. Service de Médecine Intensive Réanimation, Hôpital Saint Louis, Assistance Publique des Hôpitaux de Paris. 2. INSERM UMRS-976, Université de Paris, Paris, France

DOI:

https://doi.org/10.37051/mir-00069

Keywords:

Insuffisance rénale aiguë, réanimation, COVID-19

Abstract

Acute kidney injury (AKI) during SARS-CoV2 infection is frequent and associated with mortality. Pathophysiology of AKI is multifactorial, and encompasses specific (viral invasion, endothelitis and thrombosis, renin-angiotensin-aldosteron system activation, cytokine elevation) and unspecific mechanisms (hemodynamic instability, PEEP, nephrotoxic medications). Electrolytic disorders during SARS-CoV2 infection are markers of severity. Acute tubular necrosis is the most frequent histological lesion identified, but glomerular disease can also be observed. To date, there is no specific treatment of SARS-CoV2 induced AKI.

Published

2021-02-19

How to Cite

Gabarre, P., Dumas, G., & Zafrani, L. (2021). Acute kidney injury in patient with severe SARS-CoV-2 infection. Médecine Intensive Réanimation. https://doi.org/10.37051/mir-00069

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