Acute kidney injury in patient with severe SARS-CoV-2 infection
Keywords:Insuffisance rénale aiguë, réanimation, COVID-19
Acute kidney injury (AKI) during SARS-CoV2 infection is frequent and associated with mortality. Pathophysiology of AKI is multifactorial, and encompasses specific (viral invasion, endothelitis and thrombosis, renin-angiotensin-aldosteron system activation, cytokine elevation) and unspecific mechanisms (hemodynamic instability, PEEP, nephrotoxic medications). Electrolytic disorders during SARS-CoV2 infection are markers of severity. Acute tubular necrosis is the most frequent histological lesion identified, but glomerular disease can also be observed. To date, there is no specific treatment of SARS-CoV2 induced AKI.