Baclofen Intoxication and GABA Receptors

Authors

  • M. Beis Service de réanimation polyvalente, centre hospitalier Émile-Durkheim
  • A.-L. Druoton Service de réanimation chirurgicale Picard, hôpital Brabois
  • J. Scala-Bertola Service de pharmacologie clinique et toxicologie, hôpital Central
  • M.-J. Yehele Okouma Service de pharmacologie clinique et toxicologie, hôpital Central
  • E. Pape Service de pharmacologie clinique et toxicologie, hôpital Central
  • J.-M. Lalot Service de réanimation chirurgicale Picard, hôpital Brabois
  • P.-E. Bollaert Service de réanimation médicale, hôpital Central

DOI:

https://doi.org/10.3166/rea-2018-0035

Keywords:

Respiratory viruses, Hospital-acquired pneumonia, Pneumonia, Nosocomial

Abstract

We report a case of acute self-poisoning with baclofen. The ingested supposed dose of baclofen was 3,900 mg. The clinical pattern was that of a deep coma with bilateral fixated mydriasis, disappearance of brainstem reflex with the exception of oculocardiac reflex and spontaneous ventilation. Symptoms persisted for five days and evolved to a complete reversion of impairment and a complete restoration of the patient's state of consciousness after only symptomatic treatment. A potential interaction between baclofen and a chronic treatment with tiapride and valpromide may have participated in less toxicity of baclofen.

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Published

2018-06-12

How to Cite

Beis, M., Druoton, A.-L., Scala-Bertola, J., Yehele Okouma, M.-J., Pape, E., Lalot, J.-M., & Bollaert, P.-E. (2018). Baclofen Intoxication and GABA Receptors. Médecine Intensive Réanimation, 27(5), 475–478. https://doi.org/10.3166/rea-2018-0035

Issue

Vol. 27 No. 5 (2018): Septembre 2018 / Neuroréanimation et toxicologie

Section

Commented case report

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