Renal outcome after an acute kidney injury

Abstract

Acute kidney injury is associated with short- and long-term outcome in critically ill patients. AKI is also associated with cardiovascular events occurrence and with glomerular filtration rate decrease over time up to end-stage renal disease. This is partially related to maladaptative repair of kidney injury. Severity and duration of exposition are the two most predictive risk factors of chronic kidney disease occurrence after AKI. But the multiple hits that can occur during the ICU stay may also be involved. To date, no specific treatment is able to target this pathophysiologic mechanism; the daily practice goals to limit nephrotoxic therapeutics. A better identification of high-risk patients might help to promote new nephroprotective therapeutics.