Molecular Adsorbent Recirculating System (MARSTM) in Pediatric Intensive Care Unit

Abstract

Pediatric liver failure is a severe and life-threatening condition. Its mortality rate remains high, mainly due to encephalopathy. Extracorporeal liver supports, such as Molecular Adsorbant Recirculating System (MARS^TM), allow for safe and effective removal of albumin-bound and water-soluble substances, suspected of being responsible for the encephalopathy. Several small randomized controlled trials and case control studies in adults showed significant improvement, both in morbidity and mortality, in patients treated with MARS^TM. However, similar data is missing for children. In addition, many questions remain, such as the appropriate timing of MARS^TM treatment and its efficacy compared to other treatments, such as high-flow hemofiltration.

We are going to review the current information regarding MARS^TM treatment in adults and children.