Management of severe asthma exacerbation


  • Philippe Le Conte Service d’Accueil des Urgences, CHU de Nantes, France
  • Nicolas Terzi Service de Médecine Intensive Réanimation, CHU de Grenoble Alpes, France
  • Guillaume Mortamet Service de Réanimation Pédiatrique, CHU de Grenoble Alpes, France
  • Fekri Abroug Monastir, Tunisia
  • Guillaume Carteaux APHP, Paris
  • Céline Charasse Bordeaux
  • Anthony Chauvin APHP, Paris, France
  • Xavier Combes CHU Bordeaux, France
  • Stéphane Dauger APHP, Paris, France
  • Alexandre Demoule APHP, Paris, France
  • Thibaut Desmettre Besançon, France
  • Stéphan Ehrmann Tours, France
  • Bénédicte Gaillard-Le Roux Nantes, France
  • Valérie Hamel Toulouse, France
  • Boris Jung CHU Montpellier, France
  • Sabrina Kepka CHU Strasbourg, France
  • Erwan L’Her CHU Brest, France
  • Mikaël Martinez Montbrison, France
  • Christophe Milési Montpellier, France
  • Élise Morawiec APHP, Paris, France
  • Mathieu Oberlin CH Cahors, France
  • Patrick Plaisance APHP, Paris, France
  • Robin Pouyau Lyon, France
  • Chantal Raherison Bordeaux, France
  • Patrick Ray APHP, Paris, France
  • Matthieu Schmidt APHP, Paris, France
  • Arnaud W Thille Poitiers, France
  • Jennifer Truchot APHP, Paris, France
  • Guillaume Valdenaire Bordeaux, France
  • Julien Vaux APHP, Paris, France
  • Damien Viglino CHU Grenoble, France
  • Guillaume Voiriot APHP, Paris, France
  • Bénédicte Vrignaud CHU Nantes, France
  • Sandrine Jean Service de Réanimation Pédiatrique, APHP Hôpital Trousseau, Paris, France
  • Eric Mariotte Service de Médecine Intensive Réanimation, APHP Hôpital Saint Louis, Paris, France
  • Pierre-Géraud Claret Service d’Accueil des Urgences, CHU de Nîmes, Nîmes, France



asthma, severe exacerbation, emergency, intensive care


Background: The French Emergency Medicine Society, the French Intensive Care Society and the Pediatric Intensive Care and
Emergency Medicine French-Speaking Group edited guidelines on severe asthma exacerbation (SAE) in adult and pediatric
Results: The guidelines were related to 5 areas: diagnosis, pharmacological therapy, oxygenation and ventilation, triage and
obstetrical specifi cities. The literature analysis and formulation of the guidelines were conducted according to the Grade of
Recommendation Assessment, Development and Evaluation methodology. An extensive literature research was conducted
based on publications indexed in PubMed™ and Cochrane™ databases.
Of the 21 formalized recommendations, 4 have a high level of evidence (GRADE 1 +/-) and 7 a low level of evidence (GRADE
2 +/-). For 10 recommendations, the GRADE method could not be applied, resulting in expert opinion. A strong agreement
was reached on all the recommendations.
Conclusion: The conjunct work of 36 experts from 3 scientifi c societies resulted in 21 formalized recommendations to help
improving the emergency and intensive care management of adult and pediatric patients with SAE.




How to Cite

Le Conte, P. ., Terzi, N. ., Mortamet, G. ., Abroug, F. ., Carteaux, G. ., Charasse, C. ., Chauvin, A. ., Combes, X. ., Dauger, S. ., Demoule, A. ., Desmettre, T. ., Ehrmann, S. ., Gaillard-Le Roux, B. ., Hamel, V. ., Jung, B. ., Kepka, S. ., L’Her, E. ., Martinez, M. ., Milési, C. ., Morawiec, Élise ., Oberlin, M. ., Plaisance, P. ., Pouyau, R. ., Raherison, C. ., Ray, P. ., Schmidt, M. ., Thille, A. W. ., Truchot, J. ., Valdenaire, G. ., Vaux, J. ., Viglino, D. ., Voiriot, G. ., Vrignaud, B. ., Jean, S. ., Mariotte, E. ., & Claret, P.-G. . (2020). Management of severe asthma exacerbation. Médecine Intensive Réanimation, 29(2), 43-64.



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