Endotracheal Intubation in Septic Shock: State of the Art

Abstract

Intubation strategy during septic shock may potentially impact outcome. However, recent guidelines do not put forward any recommendation and few studies have been published on this topic. Potential benefits (improving oxygenation, diaphragmatic rest…) and side effects (intubation risk, diaphragm induced atrophy, mechanical ventilation induced lung damage, sedation induced vaspolegia…) may impact differently in every patient. Loss of consciousness or severe acute respiratory failure are straightforward indication for intubation, nevertheless, such indications do not apply in many patients. This systematic review aims at synthesizing the data on intubation from the recent largest studies on septic shock and from pathophysiological studies. Finally, the results of a post hoc analysis of the SEPSISPAM study are presented. The multicenter survey on intubation INTUBATIC is detailed (inclusion completed).