Energy and metabolism in critically ill patients: reports from the 8th Translational Research Meeting of the French Intensive Care Society (Paris, December 2nd, 2022)

Authors

  • CRT de la SRLF
  • Peter Radermacher Institut für Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Universitätsklinikum, Ulm, Germany.
  • Mehdi Oualha Service de Réanimation pédiatrique, Necker Hospital, APHP, Centre - Paris University, Paris, France
  • Laure Stiel Service de Réanimation médicale, hôpital Emile Muller, Groupe Hospitalier de Mulhouse Sud Alsace, Mulhouse France. INSERMLNC, 1231, Dijon France. LipSTIC LabEx, Dijon France.
  • Jolien Vandewalle VIB Center for Inflammation Research, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium
  • Youenn Jouan Service de Médecine Intensive Réanimation, CHRU Tours, Faculté de Médecine de Tours, INSERM U1100 Centre d'Etudes des Pathologies Respiratoires, Tours, France
  • Eric Fontaine Université Grenoble Alpes, Inserm 1055 LBFA et CHU Grenoble Alpes, service d'endocrinologie-diabétologie-nutrition, unité de nutrition artificielle, Grenoble, France
  • Jeremie Joffre Assistance Publique - Hôpitaux de Paris (AP-HP), Service de médecine intensive et réanimation, Hôpital Saint-Antoine, Sorbonne Université, Paris, France
  • Louis Kreitmann Services d'Anesthésie-réanimation médecine intensive, Hôpital Lyon Sud, Hospices Civils de Lyon, Lyon, France
  • Sarah Benghanem Service de Médecine Intensive Réanimation, Hôpital Cochin, APHP.centre, Université Paris Cité, Paris, France
  • Boris Jung Service de Médecine Intensive Réanimation, CHU Montpellier, Université de Montpellier, France
  • Manuel Schiff Service des Maladies Métaboliques Pédiatriques, Hôpital Universitaire Necker, Université Paris Cité, Inserm UMR_S1163, Institut Imagine, Paris, France
  • Alexandre Gaudet Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Centre d'Infection et d'Immunité de Lille, CHU Lille, Pôle de Médecine Intensive-Réanimation, F-59000 Lille, Franc
  • Peter Pickkers Dept Intensive Care Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
  • Benjamine Sarton Service de réanimation polyvalente, Hôpital Purpan, CHU de Toulouse - Equipe INSERM Toulouse neuroimaging center - UMR 1214, université Toulouse III, Paul Sabatier, France
  • Mette Berger Lausanne University - Faculty of Biology and Medicine, Lausanne, Switzerland
  • Tamara Merz Institut für Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Universitätsklinikum, Ulm, Germany
  • Hatem Kallel Service de Médecine Intensive Réanimation, Hôpital général de Cayenne, Guyane Française, France
  • Nicolas Bréchot Service de Médecine Intensive Réanimation, Sorbonne Université, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Assistance Publique-Hôpitaux de Paris (AP-HP), College de France, Center for Interdisciplinary Research in Biology (CIRB)-UMRS INSERM U1050 - CNRS 7241, Paris, France
  • Guillaume Voiriot Service de Médecine Intensive Réanimation, Sorbonne Université, Assistance Publique - Hôpitaux de Paris, Hôpital Tenon, Paris, France
  • Sébastien Préau Service de Médecine Intensive Réanimation, CHU Lille, U1167 - RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Université de Lille, Inserm, Institut Pasteur de Lille, F-59000 Lille, France

DOI:

https://doi.org/10.37051/mir-00184

Keywords:

Metabolism, energetic dysfunction, intensive care, mitochondrion, nutrients

Abstract

The Translational Research Committee of the French Intensive Care Society organized its annual Seminar in Paris on December 2nd, 2022. This seminar aims to bring together clinicians and scientists to discuss major research questions in the field of intensive care medicine. The topic of the 8th edition of the meeting was on challenges and promises related to research on metabolic and energetic dysfunctions in critically ill patients.

New data about expanding research on bioenergetic disorders in animal models and critically ill patients were presented. Alterations of oxygen consumption, increased levels of circulating substrates, impaired glucose and lipid oxidation, and mitochondrial dysfunction are all associated with organ dysfunction and poor outcomes in these setting. Recent understandings in substrate utilization and mitochondrial dysfunction may pave the way for new diagnostic and therapeutic approaches. These findings could help physicians to identify distinct subgroups of patients and, subsequently, to personalize treatment strategies. Implications for their use as bioenergetic targets to identify metabolism- and mitochondria-targeted treatments need to be evaluated in future studies.

The symposium proceedings were written by members of the Translational Research Committee of the French Intensive Care Society and validated by the speakers.

Image

Published

2023-12-22

How to Cite

de la SRLF, C., Radermacher, P., Oualha, M., Stiel, L., Vandewalle, J., Jouan, Y., Fontaine, E., Joffre, J., Kreitmann, L., Benghanem, S., Jung, B., Schiff, M., Gaudet, A., Pickkers, P., Sarton, B., Berger, M., Merz, T., Kallel, H., Bréchot, N., Voiriot, G., & Préau, S. (2023). Energy and metabolism in critically ill patients: reports from the 8th Translational Research Meeting of the French Intensive Care Society (Paris, December 2nd, 2022). Médecine Intensive Réanimation, 32(4), 417–428. https://doi.org/10.37051/mir-00184

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