β-Blocker in Septic Shock Management

Authors

  • M. Durand Inserm U1116, équipe 2, défaillance circulatoire aiguë et chronique, faculté de médecine de Nancy
  • H. Louis Inserm U1116, équipe 1, défaillance circulatoire aiguë et chronique, faculté de médecine de Nancy
  • C. Fritz Service de réanimation et médecine intensive Brabois, CHRU de Nancy
  • B. Levy Inserm U1116, équipe 2, défaillance circulatoire aiguë et chronique, faculté de médecine de Nancy
  • A. Kimmoun Service de réanimation et médecine intensive Brabois, CHRU de Nancy

DOI:

https://doi.org/10.3166/rea-2019-0095

Keywords:

Nutritional support, Shock, Metabolism

Abstract

Adrenoreceptors α and particularly β are the main targets of epinephrine and norepinephrine released by the sympathetic system. During septic shock, dysautonomia could be defined as a prolonged over-activation of the sympathetic system. Dysautonomia is among other abnormalities, responsible for cardiac and vascular hypo-contractility and immunosuppression. Thus, during septic shock, early administration of β-blockers might limit the deleterious effects of sympathetic over-stimulation. However, if experimental data are convincing, formal clinical evidences are still lacking.

Published

2019-03-01

How to Cite

Durand, M., Louis, H., Fritz, C., Levy, B., & Kimmoun, A. (2019). β-Blocker in Septic Shock Management. Médecine Intensive Réanimation, 28(2), 126–143. https://doi.org/10.3166/rea-2019-0095

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